Dopamine -> Dopamine_Receptor_1 Protein_Kinase_A -> Glutamate_Receptor Glutamate -> Glutamate_Receptor Protein_Phosphatase_1 -| Glutamate_Receptor Dopamine_Receptor_2 -| Adenylate_cyclase Dopamine_Receptor_1 -> Adenylate_cyclase Glutamate_Receptor -> Packaging_Proteins Dopamine -> Dopamine_Receptor_2 Protein_Kinase_A -> DARPP32 Calcineurin -| DARPP32 Packaging_Proteins -> Exocytosis Tryosine_hydroxylase -> Tryosine_hydroxylase Glutamate -> Glutamate Glutamate_Receptor -> Calcium Phospholipase_C -> Calcium Calcium -> Calcineurin Adenylate_cyclase -> Protein_Kinase_A Tryosine_hydroxylase -> Dopamine COMT -| Dopamine DARPP32 -| Protein_Phosphatase_1 Dopamine_Receptor_2 -> Phospholipase_C Dopamine -> COMT $Adenylate_cyclase: (Dopamine_Receptor_1 & !Dopamine_Receptor_2) $COMT: Dopamine $Calcineurin: Calcium $Calcium: (Phospholipase_C | Glutamate_Receptor) $DARPP32: (Protein_Kinase_A & !Calcineurin) $Dopamine: (Tryosine_hydroxylase & !COMT) $Dopamine_Receptor_1: Dopamine $Dopamine_Receptor_2: Dopamine $Exocytosis: Packaging_Proteins $Glutamate: Glutamate $Glutamate_Receptor: ((Protein_Kinase_A & Glutamate) & !Protein_Phosphatase_1) $Packaging_Proteins: Glutamate_Receptor $Phospholipase_C: Dopamine_Receptor_2 $Protein_Kinase_A: Adenylate_cyclase $Protein_Phosphatase_1: !DARPP32 $Tryosine_hydroxylase: Tryosine_hydroxylase